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Oxidative Stress in Genetic Mouse Models of Parkinson’s Disease
Joint Authors
Sarre, Sophie
Michotte, Yvette
Varçin, Mustafa
Bentea, Eduard
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
There is extensive evidence in Parkinson’s disease of a link between oxidative stress and some of the monogenically inherited Parkinson’s disease-associated genes.
This paper focuses on the importance of this link and potential impact on neuronal function.
Basic mechanisms of oxidative stress, the cellular antioxidant machinery, and the main sources of cellular oxidative stress are reviewed.
Moreover, attention is given to the complex interaction between oxidative stress and other prominent pathogenic pathways in Parkinson’s disease, such as mitochondrial dysfunction and neuroinflammation.
Furthermore, an overview of the existing genetic mouse models of Parkinson’s disease is given and the evidence of oxidative stress in these models highlighted.
Taken into consideration the importance of ageing and environmental factors as a risk for developing Parkinson’s disease, gene-environment interactions in genetically engineered mouse models of Parkinson’s disease are also discussed, highlighting the role of oxidative damage in the interplay between genetic makeup, environmental stress, and ageing in Parkinson’s disease.
American Psychological Association (APA)
Varçin, Mustafa& Bentea, Eduard& Michotte, Yvette& Sarre, Sophie. 2012. Oxidative Stress in Genetic Mouse Models of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-25.
https://search.emarefa.net/detail/BIM-486085
Modern Language Association (MLA)
Varçin, Mustafa…[et al.]. Oxidative Stress in Genetic Mouse Models of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-25.
https://search.emarefa.net/detail/BIM-486085
American Medical Association (AMA)
Varçin, Mustafa& Bentea, Eduard& Michotte, Yvette& Sarre, Sophie. Oxidative Stress in Genetic Mouse Models of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-25.
https://search.emarefa.net/detail/BIM-486085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486085