Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydrochloride
Joint Authors
Kuchekar, Bhanudas S.
Jagdale, Swati C.
Patil, Somnath
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the present study was to apply design of experiment (DOE) to optimize floating drug delivery of tapentadol hydrochloride.
Tapentadol hydrochloride is a synthetic opioid used as a centrally acting analgesic and effective in both experimental and clinical pain.
The half-life of the drug is about 4 hours and oral dose is 50 to 250 mg twice a day.
For optimization 32 full factorial design was employed for formulation of tapentadol hydrochloride tablets.
Sodium bicarbonate was incorporated as a gas-generating agent.
Combination of polymers Xanthan gum and Locust bean gum was used to achieve controlled release effect.
The concentration of polymers was considered as the independent variables and dependent variables were floating lag time and swelling index of the tablets.
From the factorial batches, it was observed that formulation containing combination of 20% sodium bicarbonate and 10% citric acid shows optimum floating ability whereas the formulation containing 20% Xanthan gum and 28% Locust bean gum shows optimum sustained drug release pattern with adequate floating.
American Psychological Association (APA)
Jagdale, Swati C.& Patil, Somnath& Kuchekar, Bhanudas S.. 2013. Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydrochloride. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486153
Modern Language Association (MLA)
Jagdale, Swati C.…[et al.]. Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydrochloride. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-486153
American Medical Association (AMA)
Jagdale, Swati C.& Patil, Somnath& Kuchekar, Bhanudas S.. Application of Design of Experiment for Floating Drug Delivery of Tapentadol Hydrochloride. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-486153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486153