Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery
Joint Authors
Wu, Chao-Jung
Kim, Go-Woon
Yang, Xiang-Jiao
Gocevski, Goran
Source
International Journal of Cell Biology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Healthy lifestyles and environment produce a good state of health.
A number of scientific studies support the notion that external stimuli regulate an individual's epigenomic profile.
Epigenetic changes play a key role in defining gene expression patterns under both normal and pathological conditions.
As a major posttranslational modification, lysine (K) acetylation has received much attention, owing largely to its significant effects on chromatin dynamics and other cellular processes across species.
Lysine acetyltransferases and deacetylases, two opposing families of enzymes governing K-acetylation, have been intimately linked to cancer and other diseases.
These enzymes have been pursued by vigorous efforts for therapeutic development in the past 15 years or so.
Interestingly, certain dietary components have been found to modulate acetylation levels in vivo.
Here we review dietary, metabolic, and environmental modulators of the K-acetylation machinery and discuss how they may be of potential value in the context of disease prevention.
American Psychological Association (APA)
Kim, Go-Woon& Gocevski, Goran& Wu, Chao-Jung& Yang, Xiang-Jiao. 2010. Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery. International Journal of Cell Biology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-486781
Modern Language Association (MLA)
Kim, Go-Woon…[et al.]. Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery. International Journal of Cell Biology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-486781
American Medical Association (AMA)
Kim, Go-Woon& Gocevski, Goran& Wu, Chao-Jung& Yang, Xiang-Jiao. Dietary, Metabolic, and Potentially Environmental Modulation of the Lysine Acetylation Machinery. International Journal of Cell Biology. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-486781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486781