Development of LC Method for the Simultaneous Determination of Antidepressant Drug Combination Melitracen Hydrochloride and Flupentixol Dihydrochloride in their Combined Dosage Form
Joint Authors
Bhatt, Kashyap K.
Baldania, Sunil L.
Chhalotiya, Usmangani K.
Shah, Dimal A.
Chauhan, Gautam R.
Source
Chromatography Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A simple, specific and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of melitracen hydrochloride and flupentixol dihydrochloride in tablet dosage form.
A Brownlee C-18, 5 μm column having 250×4.6 mm i.d.
in isocratic mode, with mobile phase containing 0.025 M potassium dihydrogen phosphate: methanol (10 : 90, v/v; pH 7.3) was used.
The flow rate was 1.0 mL/min, and effluents were monitored at 230 nm.
The retention times of melitracen hydrochloride and flupentixol dihydrochloride were 7.75 min and 5.50 min, respectively.
The linearity for melitracen hydrochloride and flupentixol dihydrochloride were in the range of 0.5–60 μg/mL.
The recoveries obtained for melitracen hydrochloride and flupenthixol dihydrochloride was 99.81–100.77% and 99.42–100.12%, respectively.
Both the drugs were subjected to acid and alkali hydrolysis, chemical oxidation, and dry heat degradation and photodegradation.
The proposed method was validated and successfully applied to the estimation of melitracen hydrochloride and flupentixol dihydrochloride in combined tablet dosage form.
American Psychological Association (APA)
Chhalotiya, Usmangani K.& Bhatt, Kashyap K.& Shah, Dimal A.& Chauhan, Gautam R.& Baldania, Sunil L.. 2011. Development of LC Method for the Simultaneous Determination of Antidepressant Drug Combination Melitracen Hydrochloride and Flupentixol Dihydrochloride in their Combined Dosage Form. Chromatography Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-486789
Modern Language Association (MLA)
Chhalotiya, Usmangani K.…[et al.]. Development of LC Method for the Simultaneous Determination of Antidepressant Drug Combination Melitracen Hydrochloride and Flupentixol Dihydrochloride in their Combined Dosage Form. Chromatography Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-486789
American Medical Association (AMA)
Chhalotiya, Usmangani K.& Bhatt, Kashyap K.& Shah, Dimal A.& Chauhan, Gautam R.& Baldania, Sunil L.. Development of LC Method for the Simultaneous Determination of Antidepressant Drug Combination Melitracen Hydrochloride and Flupentixol Dihydrochloride in their Combined Dosage Form. Chromatography Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-486789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486789