Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis : A Review
Joint Authors
Fahim, Ahmed
Hart, Simon P.
Crooks, Michael
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The histological counterpart of idiopathic pulmonary fibrosis is usual interstitial pneumonia, in which areas of fibrosis of various ages are interspersed with normal lung.
This pattern could be explained by repeated episodes of lung injury followed by abnormal wound healing responses.
The cause of the initiating alveolar epithelial injury is unknown, but postulated mechanisms include immunological, microbial, or chemical injury, including aspirated gastric refluxate.
Reflux is promoted by low basal pressure in the lower oesophageal sphincter and frequent relaxations, potentiated by hiatus hernia or oesophageal dysmotility.
In susceptible individuals, repeated microaspiration of gastric refluxate may contribute to the pathogenesis of IPF.
Microaspiration of nonacid or gaseous refluxate is poorly detected by current tests for gastroesophageal reflux which were developed for investigating oesophageal symptoms.
Further studies using pharyngeal pH probes, high-resolution impedance manometry, and measurement of pepsin in the lung should clarify the impact of reflux and microaspiration in the pathogenesis of IPF.
American Psychological Association (APA)
Fahim, Ahmed& Crooks, Michael& Hart, Simon P.. 2010. Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis : A Review. Pulmonary Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486869
Modern Language Association (MLA)
Fahim, Ahmed…[et al.]. Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis : A Review. Pulmonary Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-486869
American Medical Association (AMA)
Fahim, Ahmed& Crooks, Michael& Hart, Simon P.. Gastroesophageal Reflux and Idiopathic Pulmonary Fibrosis : A Review. Pulmonary Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-486869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-486869