Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox

Joint Authors

Ragle, James Matthew
Barberán-Soler, Sergio

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-08-28

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Alternative splicing allows for the generation of protein diversity and fine-tunes gene expression.

Several model systems have been used for the in vivo study of alternative splicing.

Here we review the use of the nematode Caenorhabditis elegans to study splicing regulation in vivo.

Recent studies have shown that close to 25% of genes in the worm genome undergo alternative splicing.

A big proportion of these events are functional, conserved, and under strict regulation either across development or other conditions.

Several techniques like genome-wide RNAi screens and bichromatic reporters are available for the study of alternative splicing in worms.

In this review, we focus, first, on the main studies that have been performed to dissect alternative splicing in this system and later on examples from genes that have human homologs that are implicated in cancer.

The significant advancement towards understanding the regulation of alternative splicing and cancer that the C.

elegans system has offered is discussed.

American Psychological Association (APA)

Barberán-Soler, Sergio& Ragle, James Matthew. 2013. Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487016

Modern Language Association (MLA)

Barberán-Soler, Sergio& Ragle, James Matthew. Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox. International Journal of Cell Biology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-487016

American Medical Association (AMA)

Barberán-Soler, Sergio& Ragle, James Matthew. Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487016

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-487016