Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox
Joint Authors
Ragle, James Matthew
Barberán-Soler, Sergio
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alternative splicing allows for the generation of protein diversity and fine-tunes gene expression.
Several model systems have been used for the in vivo study of alternative splicing.
Here we review the use of the nematode Caenorhabditis elegans to study splicing regulation in vivo.
Recent studies have shown that close to 25% of genes in the worm genome undergo alternative splicing.
A big proportion of these events are functional, conserved, and under strict regulation either across development or other conditions.
Several techniques like genome-wide RNAi screens and bichromatic reporters are available for the study of alternative splicing in worms.
In this review, we focus, first, on the main studies that have been performed to dissect alternative splicing in this system and later on examples from genes that have human homologs that are implicated in cancer.
The significant advancement towards understanding the regulation of alternative splicing and cancer that the C.
elegans system has offered is discussed.
American Psychological Association (APA)
Barberán-Soler, Sergio& Ragle, James Matthew. 2013. Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487016
Modern Language Association (MLA)
Barberán-Soler, Sergio& Ragle, James Matthew. Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox. International Journal of Cell Biology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-487016
American Medical Association (AMA)
Barberán-Soler, Sergio& Ragle, James Matthew. Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans : An In Vivo Model System with a Powerful Reverse Genetics Toolbox. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487016