7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NCNga Mice
Joint Authors
Kim, Bo-Bae
Kang, Nam Joo
Kim, Jong Rhan
Lee, Ki Won
Kim, Young Ah
Joo Lee, Hyong
Yeom, Myeong-Hun
Park, Jun Seong
Kim, Ji Hye
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Atopic dermatitis is an inflammatory and chronically relapsing skin disorder that commonly occurs in children; the number of atopic dermatitis patients is increasing.
The cause and mechanism of atopic dermatitis have not been defined clearly, although many studies are ongoing.
Epidemiological studies suggest that soybean and its isoflavones have immunoregulatory activities.
Here, we report that 7,3′,4′-trihydroxyisoflavone (7,3′,4′-THIF), a major metabolite of daidzin, effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced β-hexosaminidase secretion in RBL-2H3 cells.
Moreover, 7,3′,4′-THIF significantly reduced scratching time, transepidermal water loss, and mast cell infiltration.
It also decreased protease-activated receptor (PAR)-2 and IL-4 expression and increased filaggrin expression in skin lesions of NC/Nga mice.
These results suggest that 7,3′,4′-THIF improves Dermatophagoides farina body extract-induced atopic dermatitis in NC/Nga mice.
American Psychological Association (APA)
Kim, Bo-Bae& Kim, Jong Rhan& Kim, Ji Hye& Kim, Young Ah& Park, Jun Seong& Yeom, Myeong-Hun…[et al.]. 2013. 7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NCNga Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487065
Modern Language Association (MLA)
Kim, Bo-Bae…[et al.]. 7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NCNga Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-487065
American Medical Association (AMA)
Kim, Bo-Bae& Kim, Jong Rhan& Kim, Ji Hye& Kim, Young Ah& Park, Jun Seong& Yeom, Myeong-Hun…[et al.]. 7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NCNga Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487065
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487065