Histone Acetyltransferases as Regulators of Nonhistone Proteins : The Role of Interferon Regulatory Factor Acetylation on Gene Transcription
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
When studying transcription factors, it is necessary to investigate posttranslational modifications.
Histone acetyltransferases (HATs) are typical of the modification enzymes involved in chromatin regulation.
HATs acetylate the transcription factors (nonhistone proteins) as well as histones.
Interferon regulatory factors (IRFs) are transcription factors that bind to the interferon regulatory element (IRF-E) and are involved in regulating cell growth, differentiation, and the immune and hematopoietic systems.
During the process of binding to a specific DNA element, IRFs also bind to coactivators such as HATs and become modified.
This review looks at how IRFs associate with HATs, p300, and PCAF, and thereby contribute to transcriptional activation.
American Psychological Association (APA)
Masumi, Atsuko. 2010. Histone Acetyltransferases as Regulators of Nonhistone Proteins : The Role of Interferon Regulatory Factor Acetylation on Gene Transcription. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-487433
Modern Language Association (MLA)
Masumi, Atsuko. Histone Acetyltransferases as Regulators of Nonhistone Proteins : The Role of Interferon Regulatory Factor Acetylation on Gene Transcription. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-487433
American Medical Association (AMA)
Masumi, Atsuko. Histone Acetyltransferases as Regulators of Nonhistone Proteins : The Role of Interferon Regulatory Factor Acetylation on Gene Transcription. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-487433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487433