NAG-1GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response
Joint Authors
Zeldin, D. C.
Kim, J. K.
Baek, Seung Joon
Kim, J. M.
Kosak, J. P.
Kissling, Grace E.
Bradbury, J. A.
Eling, T. E.
Germolec, D. R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
NAG-1/GDF15 is a TGF-β superfamily member with poorly characterized biological activity proposed to inhibit inflammatory cytokine production.
Transgenic mice expressing human NAG-1/GDF15 (NAG-1Tg/Lox) are leaner with lower body weight and are resistant to chemically or genetically induced intestinal tumors.
Because of the link between obesity, inflammation, and cancer, we examined whether these mice exhibit a reduced response to inflammatory stimuli.
The NAG-1Tg/Lox mice had a reduced inflammatory response to LPS based on the serum levels of cytokines KC, IL-6, MCP-1, and TNFα.
In contrast to literature reports and our in vivo results, NAG-1 did not inhibit LPS-induced cytokine expression in vitro in RAW264.7 cells, mouse peritoneal macrophages, or mouse liver Kupffer cells, suggesting that NAG-1/GDF15 does not directly inhibit LPS-induced inflammatory cytokine production.
However, NAG-1Tg/Lox mice have less white adipose tissue, the major source of inflammatory adipokines including leptin.
Basal and LPS-treated serum leptin and mRNA levels in the adipose tissue of NAG-1Tg/Lox mice were lower than those in WT mice.
We propose that the reduced white adipose tissue and reduced leptin expression may be responsible, in part, for the reduced inflammatory response to LPS and the decrease in intestinal tumors observed in NAG-1Tg/Lox mice.
American Psychological Association (APA)
Kim, J. M.& Kosak, J. P.& Kim, J. K.& Kissling, Grace E.& Germolec, D. R.& Zeldin, D. C.…[et al.]. 2013. NAG-1GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487551
Modern Language Association (MLA)
Kim, J. M.…[et al.]. NAG-1GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-487551
American Medical Association (AMA)
Kim, J. M.& Kosak, J. P.& Kim, J. K.& Kissling, Grace E.& Germolec, D. R.& Zeldin, D. C.…[et al.]. NAG-1GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487551