Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity
Joint Authors
Lania, Luigi
Majello, Barbara
Napolitano, Giuliana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
P-TEFb is a transcriptional factor that specifically regulates the elongation step of RNA polymerase II-dependent transcription and its activity strictly required for Human Immunodeficiency Virus (HIV) infection and during cardiac differentiation.
P-TEFb role has emerged as a crucial regulator of transcription elongation and its activity found finely tuned in vivo at transcriptional level as well as posttranscriptionally by dynamic association with different multisubunit molecular particles.
Both physiological and pathological cellular signals rapidly converge on P-TEFb regulation by modifying expression and activity of the complex to allow cells to properly respond to different stimuli.
In this review we will give a panoramic view on P-TEFb regulation by noncoding RNAs in both physiological and pathological conditions.
American Psychological Association (APA)
Napolitano, Giuliana& Lania, Luigi& Majello, Barbara. 2014. Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-487713
Modern Language Association (MLA)
Napolitano, Giuliana…[et al.]. Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-487713
American Medical Association (AMA)
Napolitano, Giuliana& Lania, Luigi& Majello, Barbara. Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-487713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487713