C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The prevalence of obesity has given rise to significant global concerns as numerous population-based studies demonstrate an incontrovertible association between obesity and breast cancer.
Mechanisms proposed to account for this linkage include exaggerated levels of carbohydrate substrates, elevated levels of circulating mitogenic hormones, and inflammatory cytokines that impinge on epithelial programming in many tissues.
Moreover, recently many scientists have rediscovered the observation, first described by Otto Warburg nearly a century ago, that most cancer cells undergo a dramatic metabolic shift in energy utilization and expenditure that fuels and supports the cellular expansion associated with malignant proliferation.
This shift in substrate oxidation comes at the cost of sharp changes in the levels of the high energy intermediate, nicotinamide adenine dinucleotide (NADH).
In this review, we discuss a novel example of how shifts in the concentration and flux of substrates metabolized and generated during carbohydrate metabolism represent components of a signaling network that can influence epigenetic regulatory events in the nucleus.
We refer to this regulatory process as “metabolic transduction” and describe how the C-terminal binding protein (CtBP) family of NADH-dependent nuclear regulators represents a primary example of how cellular metabolic status can influence epigenetic control of cellular function and fate.
American Psychological Association (APA)
Byun, Jung S.& Gardner, Kevin. 2013. C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487985
Modern Language Association (MLA)
Byun, Jung S.& Gardner, Kevin. C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. International Journal of Cell Biology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-487985
American Medical Association (AMA)
Byun, Jung S.& Gardner, Kevin. C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487985