C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer

Joint Authors

Byun, Jung S.
Gardner, Kevin

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-05-20

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Biology

Abstract EN

The prevalence of obesity has given rise to significant global concerns as numerous population-based studies demonstrate an incontrovertible association between obesity and breast cancer.

Mechanisms proposed to account for this linkage include exaggerated levels of carbohydrate substrates, elevated levels of circulating mitogenic hormones, and inflammatory cytokines that impinge on epithelial programming in many tissues.

Moreover, recently many scientists have rediscovered the observation, first described by Otto Warburg nearly a century ago, that most cancer cells undergo a dramatic metabolic shift in energy utilization and expenditure that fuels and supports the cellular expansion associated with malignant proliferation.

This shift in substrate oxidation comes at the cost of sharp changes in the levels of the high energy intermediate, nicotinamide adenine dinucleotide (NADH).

In this review, we discuss a novel example of how shifts in the concentration and flux of substrates metabolized and generated during carbohydrate metabolism represent components of a signaling network that can influence epigenetic regulatory events in the nucleus.

We refer to this regulatory process as “metabolic transduction” and describe how the C-terminal binding protein (CtBP) family of NADH-dependent nuclear regulators represents a primary example of how cellular metabolic status can influence epigenetic control of cellular function and fate.

American Psychological Association (APA)

Byun, Jung S.& Gardner, Kevin. 2013. C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487985

Modern Language Association (MLA)

Byun, Jung S.& Gardner, Kevin. C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. International Journal of Cell Biology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-487985

American Medical Association (AMA)

Byun, Jung S.& Gardner, Kevin. C-Terminal Binding Protein : A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-487985

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-487985