Differential Effect of the Dopamine D3 Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion
Joint Authors
De La Cruz, Fidel
Garcés-Ramírez, Linda
Zamudio, Sergio R.
Guzmán-Velázquez, Sonia
Flores, Gonzalo
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The neonatal ventral hippocampal lesion (nVHL) has been widely used as an animal model for schizophrenia.
Rats with an nVHL show several delayed behavioral alterations that mimic some symptoms of schizophrenia.
Sprague-Dawley (SD) rats with an nVHL have a decrease in D3 receptors in limbic areas, but the expression of D3 receptors in Wistar (W) rats with an nVHL is unknown.
The 7-Hydroxy-2-(N,N-di-n-propylamino) tetralin (7-OH-DPAT) has been reported as a D3-preferring agonist.
Thus, we investigated the effect of (±)-7-OH-DPAT (0.25 mg/kg) on the motor activity in male adult W and SD rats after an nVHL.
The 7-OH-DPAT caused a decrease in locomotion of W rats with an nVHL, but it did not change the locomotion of SD rats with this lesion.
Our results suggest that the differential effect of 7-OH-DPAT between W and SD rats with an nVHL could be caused by a different expression of the D3 receptors.
These results may have implications for modeling interactions of genetic and environmental factors involved in schizophrenia.
American Psychological Association (APA)
Guzmán-Velázquez, Sonia& Garcés-Ramírez, Linda& Flores, Gonzalo& De La Cruz, Fidel& Zamudio, Sergio R.. 2011. Differential Effect of the Dopamine D3 Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion. International Journal of Medicinal Chemistry،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488075
Modern Language Association (MLA)
Guzmán-Velázquez, Sonia…[et al.]. Differential Effect of the Dopamine D3 Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion. International Journal of Medicinal Chemistry No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-488075
American Medical Association (AMA)
Guzmán-Velázquez, Sonia& Garcés-Ramírez, Linda& Flores, Gonzalo& De La Cruz, Fidel& Zamudio, Sergio R.. Differential Effect of the Dopamine D3 Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion. International Journal of Medicinal Chemistry. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488075