Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome
Joint Authors
Nakazato, Kazuhiko
Sawamura, Tatsuya
Misaka, Tomofumi
Saitoh, Shu-ichi
Sakamoto, Nobuo
Sugimoto, Koichi
Suzuki, Satoshi
Takeishi, Yasuchika
Ishibashi, Toshiyuki
Yamaki, Takayoshi
Kunii, Hiroyuki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined.
Methods.
Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI.
Results.
We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (P<0.01, for both).
The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (P<0.01, for both).
The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (P<0.01, for both).
Receiver operating characteristic curves for ACS detection demonstrated high sensitivity and specificity for the soluble LOX-1 and LOX-1 index with no differences between the Ao and CS.
Conclusions.
The present study showed that circulating soluble LOX-1 originates from coronary circulation and soluble LOX-1 and LOX-1 index are useful biomarkers for ACS.
American Psychological Association (APA)
Misaka, Tomofumi& Suzuki, Satoshi& Sakamoto, Nobuo& Yamaki, Takayoshi& Sugimoto, Koichi& Kunii, Hiroyuki…[et al.]. 2014. Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-488102
Modern Language Association (MLA)
Misaka, Tomofumi…[et al.]. Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-488102
American Medical Association (AMA)
Misaka, Tomofumi& Suzuki, Satoshi& Sakamoto, Nobuo& Yamaki, Takayoshi& Sugimoto, Koichi& Kunii, Hiroyuki…[et al.]. Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-488102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488102