Silica-Coated Liposomes for Insulin Delivery
Joint Authors
Arunagirinathan, M. A.
Bellare, Jayesh
Dwivedi, Neelam
Sharma, Somesh
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency.
Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, and layer of silica was formed above lipid bilayer by acid catalysis.
The presence of silica coating and encapsulated insulin was identified using confocal and electron microscopy.
The native state of insulin present in the formulation was evident from Confocal Micro-Raman spectroscopy.
Silica coat enhances the stability of insulin-loaded delivery vehicles.
In vivo study shows that these silica coated formulations were biologically active in reducing glucose levels.
American Psychological Association (APA)
Dwivedi, Neelam& Arunagirinathan, M. A.& Sharma, Somesh& Bellare, Jayesh. 2010. Silica-Coated Liposomes for Insulin Delivery. Journal of Nanomaterials،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-488387
Modern Language Association (MLA)
Dwivedi, Neelam…[et al.]. Silica-Coated Liposomes for Insulin Delivery. Journal of Nanomaterials No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-488387
American Medical Association (AMA)
Dwivedi, Neelam& Arunagirinathan, M. A.& Sharma, Somesh& Bellare, Jayesh. Silica-Coated Liposomes for Insulin Delivery. Journal of Nanomaterials. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-488387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488387
