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Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs
Joint Authors
Ly, Danith H.
Bahal, Raman
Rapireddy, Srinivas
Sacui, Iulia
Crawford, Matthew J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains.
The effects of these side-chains on the conformations and hybridization properties of PNAs were determined using a combination of CD and UV-Vis spectroscopic techniques.
Our results show that the γ-position can accommodate varying degrees of sterically hindered side-chains, reaffirming the bimodal function of PNAs as the true hybrids of “peptides” and “nucleic acids.”
American Psychological Association (APA)
Crawford, Matthew J.& Rapireddy, Srinivas& Bahal, Raman& Sacui, Iulia& Ly, Danith H.. 2011. Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-488462
Modern Language Association (MLA)
Crawford, Matthew J.…[et al.]. Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs. Journal of Nucleic Acids No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-488462
American Medical Association (AMA)
Crawford, Matthew J.& Rapireddy, Srinivas& Bahal, Raman& Sacui, Iulia& Ly, Danith H.. Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-488462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488462