Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease
Joint Authors
Shimizu, Takahiko
Murakami, Kazuma
Irie, Kazuhiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxidative stress is closely involved in age-related diseases and ageing itself.
There is evidence of the leading contribution of oxidative damage to neurodegenerative disease, in contrast to other diseases where oxidative stress plays a secondary role.
The 42-mer amyloid β (Aβ42) peptide is thought to be a culprit in the pathogenesis of Alzheimer's disease (AD).
Aβ42 aggregates form the oligomeric assembly and show neurotoxicity, causing synaptic dysfunction.
Aβ42 also induces tissue oxidation (DNA/RNA, proteins, and lipids) through trace metals (Cu, Zn, and Fe), which can be protected by antioxidant enzymes, vitamin C, and vitamin E.
Superoxide dismutase catalyzes the conversion of toxic superoxide radical to less reactive hydrogen peroxide, contributing to protection from AD.
Here we review the involvement of oxidative stress in AD progression induced from an imbalance between the radical formation of Aβ42 itself together with unique turn structure at positions Glu22 and Asp23 and several defense systems.
American Psychological Association (APA)
Murakami, Kazuma& Shimizu, Takahiko& Irie, Kazuhiro. 2011. Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-488604
Modern Language Association (MLA)
Murakami, Kazuma…[et al.]. Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. Journal of Amino Acids No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-488604
American Medical Association (AMA)
Murakami, Kazuma& Shimizu, Takahiko& Irie, Kazuhiro. Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-488604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488604