Clinical and Microbiological Determinants of Outcome in Staphylococcus aureus Bacteraemia
Joint Authors
Cubbon, Marc
Paul, John
Baker, Gillian
Lindsay, Jodi
Heath, Ian
Enright, Mark C.
Curtis, Sally
Llewelyn, Martin
Walker-Bone, Karen
Price, James
Source
International Journal of Microbiology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Staphylococcus aureus bacteraemia (SAB) is commonly complicated by metastatic infection or relapse after treatment.
Objectives.
The study aim was to determine the role of bacterial, host, and management factors in development of complicated SAB.
Methods.
A prospectively-conducted observational study gathered data on predisposition, management and outcome of 100 consecutive SAB cases.
Antibiotic susceptibilities and genetic lineage of bacterial isolates were determined.
Further clinical and microbiological data were gathered on two retrospective series from 1999–2000 (n=57) and 2004 (n=116).
Results.
In the prospective cases, 27% met our definition of complicated disease.
Expressed as RR and 95% CI, complicated disease was associated with diabetes (1.58, 1.00–2.48), injecting-drug use (5.48, 0.88–33.49), community-onset of symptoms (1.4, 1.02–1.92), and symptom duration ≥48 hours prior to starting effective antibiotic therapy (2.10, 1.22–3.61).
Uncomplicated disease was associated with the presence of a central line (0.69, 0.55–0.88) and prompt removal of a primary focus (0.71, 0.57–0.90).
Neither methicillin resistance nor genetic lineage was associated with complicated disease, but methicillin resistance was associated with higher mortality.
Conclusions.
This study demonstrates that clinical rather than microbial factors are the major determinants of SAB outcome and underscores the importance of early treatment.
American Psychological Association (APA)
Price, James& Baker, Gillian& Heath, Ian& Walker-Bone, Karen& Cubbon, Marc& Curtis, Sally…[et al.]. 2010. Clinical and Microbiological Determinants of Outcome in Staphylococcus aureus Bacteraemia. International Journal of Microbiology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-488668
Modern Language Association (MLA)
Price, James…[et al.]. Clinical and Microbiological Determinants of Outcome in Staphylococcus aureus Bacteraemia. International Journal of Microbiology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-488668
American Medical Association (AMA)
Price, James& Baker, Gillian& Heath, Ian& Walker-Bone, Karen& Cubbon, Marc& Curtis, Sally…[et al.]. Clinical and Microbiological Determinants of Outcome in Staphylococcus aureus Bacteraemia. International Journal of Microbiology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-488668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488668