Inflammasome in Intestinal Inflammation and Cancer
Joint Authors
de Souza, Heitor S.
Nunes, Tiago
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The activation of specific cytosolic pathogen recognition receptors, the nucleotide-binding-oligomerization-domain- (NOD-) like receptors (NLRs), leads to the assembly of the inflammasome, a multimeric complex platform that activates caspase-1.
The caspase-1 pathway leads to the upregulation of important cytokines from the interleukin (IL)-1 family, IL-1β, and IL-18, with subsequent activation of the innate immune response.
In this review, we discuss the molecular structure, the mechanisms behind the inflammasome activation, and its possible role in the pathogenesis of inflammatory bowel diseases and intestinal cancer.
Here, we show that the available data points towards the importance of the inflammasome in the innate intestinal immune response, being the complex involved in the maintenance of intestinal homeostasis, correct intestinal barrier function and efficient elimination of invading pathogens.
American Psychological Association (APA)
Nunes, Tiago& de Souza, Heitor S.. 2013. Inflammasome in Intestinal Inflammation and Cancer. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-488680
Modern Language Association (MLA)
Nunes, Tiago& de Souza, Heitor S.. Inflammasome in Intestinal Inflammation and Cancer. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-488680
American Medical Association (AMA)
Nunes, Tiago& de Souza, Heitor S.. Inflammasome in Intestinal Inflammation and Cancer. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-488680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488680