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Immunoneutralization of TGFβ1 Improves Skeletal Muscle Regeneration : Effects on Myoblast Differentiation and Glycosaminoglycan Content
Joint Authors
Dragun, P.
Zimowska, M.
Moraczewski, J.
Oberbek, A.
Duchesnay, A.
Martelly, I.
Source
International Journal of Cell Biology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
When injured by crushing, the repair of the slow-twitch soleus rat muscle, unlike the fast-twitch EDL, is associated with fibrosis.
As TGFβ1, whose activity can be controlled by glycosaminoglycans (GAG), plays a major role in fibrosis, we hypothesized that levels of TGFβ1 and GAG contents could account for this differential quality of regeneration.
Here we show that the regeneration of the soleus was accompanied by elevated and more sustained TGFβ1 level than in the EDL.
Neutralization of TGFβ1 effects by antibodies to TGFβ1 or its receptor TGFβ-R1 improved muscle repair, especially of the soleus muscle, increased in vitro growth of myoblasts, and accelerated their differentiation.
These processes were accompanied by alterations of GAG contents.
These results indicate that the control of TGFβ1 activity is important to improve regeneration of injured muscle and accelerate myoblast differentiation, in part through changes in GAG composition of muscle cell environment.
American Psychological Association (APA)
Zimowska, M.& Duchesnay, A.& Dragun, P.& Oberbek, A.& Moraczewski, J.& Martelly, I.. 2009. Immunoneutralization of TGFβ1 Improves Skeletal Muscle Regeneration : Effects on Myoblast Differentiation and Glycosaminoglycan Content. International Journal of Cell Biology،Vol. 2009, no. 2009, pp.1-16.
https://search.emarefa.net/detail/BIM-488996
Modern Language Association (MLA)
Zimowska, M.…[et al.]. Immunoneutralization of TGFβ1 Improves Skeletal Muscle Regeneration : Effects on Myoblast Differentiation and Glycosaminoglycan Content. International Journal of Cell Biology No. 2009 (2009), pp.1-16.
https://search.emarefa.net/detail/BIM-488996
American Medical Association (AMA)
Zimowska, M.& Duchesnay, A.& Dragun, P.& Oberbek, A.& Moraczewski, J.& Martelly, I.. Immunoneutralization of TGFβ1 Improves Skeletal Muscle Regeneration : Effects on Myoblast Differentiation and Glycosaminoglycan Content. International Journal of Cell Biology. 2009. Vol. 2009, no. 2009, pp.1-16.
https://search.emarefa.net/detail/BIM-488996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488996