The Importance of C4d in Biopsies of Kidney Transplant Recipients
Joint Authors
Corrêa, Rosana Rosa Miranda
Vinícius da Silva, Marcos
Guimarães, Camila Souza de Oliveira
Reis, Marlene Antônia dos
Helmo, Fernanda Rodrigues
Rocha, Laura Penna
Machado, Juliana Reis
Faleiros, Ana Carolina Guimarães
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Antibody-mediated rejection (AMR) is highly detrimental to the prolonged survival of transplanted kidneys.
C4d has been regarded as a footprint of AMR tissue damage, and the introduction of C4d staining in daily clinical practice aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection.
Despite the general acceptance of the usefulness of C4d in the identification of acute AMR, the data for C4d staining in chronic AMR is variable.
The presence of C4d in the majority of the biopsies with features of chronic antibody-mediated rejection is reported, but this rejection without C4d staining is observed as well, suggesting that C4d is specific but not sensitive.
Further studies on AMR with positive C4d staining in biopsy specimens are really important, as well as the study of novel routine markers that may participate in the pathogenesis of this process.
American Psychological Association (APA)
Corrêa, Rosana Rosa Miranda& Machado, Juliana Reis& Vinícius da Silva, Marcos& Helmo, Fernanda Rodrigues& Guimarães, Camila Souza de Oliveira& Rocha, Laura Penna…[et al.]. 2013. The Importance of C4d in Biopsies of Kidney Transplant Recipients. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-489743
Modern Language Association (MLA)
Corrêa, Rosana Rosa Miranda…[et al.]. The Importance of C4d in Biopsies of Kidney Transplant Recipients. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-489743
American Medical Association (AMA)
Corrêa, Rosana Rosa Miranda& Machado, Juliana Reis& Vinícius da Silva, Marcos& Helmo, Fernanda Rodrigues& Guimarães, Camila Souza de Oliveira& Rocha, Laura Penna…[et al.]. The Importance of C4d in Biopsies of Kidney Transplant Recipients. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-489743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-489743