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Neuroprotective Function of DJ-1 in Parkinson’s Disease
Joint Authors
Maita, Hiroshi
Kato, Izumi
Takahashi-Niki, Kazuko
Ariga, Hiroyoshi
Iguchi-Ariga, Sanae M. M.
Niki, Takeshi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Parkinson’s disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum.
Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration in PD.
Although genetic and environmental factors are thought to affect the onset of PD, precise mechanisms at the molecular level have not been elucidated.
The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene.
DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1.
Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer’s disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD.
DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress.
In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD.
American Psychological Association (APA)
Ariga, Hiroyoshi& Takahashi-Niki, Kazuko& Kato, Izumi& Maita, Hiroshi& Niki, Takeshi& Iguchi-Ariga, Sanae M. M.. 2013. Neuroprotective Function of DJ-1 in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490290
Modern Language Association (MLA)
Ariga, Hiroyoshi…[et al.]. Neuroprotective Function of DJ-1 in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-490290
American Medical Association (AMA)
Ariga, Hiroyoshi& Takahashi-Niki, Kazuko& Kato, Izumi& Maita, Hiroshi& Niki, Takeshi& Iguchi-Ariga, Sanae M. M.. Neuroprotective Function of DJ-1 in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-490290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490290