Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD
Joint Authors
Younossi, Zobair M.
Afendy, Arian
Baranova, Ancha
Chandhoke, Vikas
Elariny, Hazem
Neupane, Arpan
Shamsaddini, Amirhossein
Birerdinc, Aybike
Mehta, Rohini
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity is associated with chronic low-grade inflammation perpetuated by visceral adipose.
Other organs, particularly stomach and intestine, may also overproduce proinflammatory molecules.
We examined the gene expression patterns in gastric tissue of morbidly obese patients with nonalcoholic fatty liver disease (NAFLD) and compared the changes in gene expression in different histological forms of NAFLD.
Stomach tissue samples from 20 morbidly obese NAFLD patients who were undergoing sleeve gastrectomy were profiled using qPCR for 84 genes encoding inflammatory cytokines, chemokines, their receptors, and other components of inflammatory cascades.
Interleukin 8 receptor-beta (IL8RB) gene overexpression in gastric tissue was correlated with the presence of hepatic steatosis, hepatic fibrosis, and histologic diagnosis of nonalcoholic steatohepatitis (NASH).
Expression levels of soluble interleukin 1 receptor antagonist (IL1RN) were correlated with the presence of NASH and hepatic fibrosis.
mRNA levels of interleukin 8 (IL8), chemokine (C-C motif) ligand 4 (CCL4), and its receptor chemokine (C-C motif) receptor type 5 (CCR5) showed a significant increase in patients with advanced hepatic inflammation and were correlated with the severity of the hepatic inflammation.
The results of our study suggest that changes in expression patterns for inflammatory molecule encoding genes within gastric tissue may contribute to the pathogenesis of obesity-related NAFLD.
American Psychological Association (APA)
Mehta, Rohini& Birerdinc, Aybike& Neupane, Arpan& Shamsaddini, Amirhossein& Afendy, Arian& Elariny, Hazem…[et al.]. 2013. Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-490331
Modern Language Association (MLA)
Mehta, Rohini…[et al.]. Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-490331
American Medical Association (AMA)
Mehta, Rohini& Birerdinc, Aybike& Neupane, Arpan& Shamsaddini, Amirhossein& Afendy, Arian& Elariny, Hazem…[et al.]. Expression of Inflammation-Related Genes Is Altered in Gastric Tissue of Patients with Advanced Stages of NAFLD. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-490331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490331