Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
Joint Authors
Ivars, David
Tormos, Carmen
Miguel, Amparo
Collado, Rosa
Egea, Mercedes
Carbonell, Félix
Oliver, Isabel
Sáez, Guillermo T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown.
We recruited 55 untreated CLL patients and assessed 8-oxo-2′-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) levels, and we compared them among the cytogenetic subgroups established using fluorescence in situ hybridization (FISH).
Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group.
TP53 deletion patients exhibited a diminished DNA repair efficiency.
Finally, cases with normal FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes.
American Psychological Association (APA)
Collado, Rosa& Ivars, David& Oliver, Isabel& Tormos, Carmen& Egea, Mercedes& Miguel, Amparo…[et al.]. 2014. Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-490545
Modern Language Association (MLA)
Collado, Rosa…[et al.]. Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-490545
American Medical Association (AMA)
Collado, Rosa& Ivars, David& Oliver, Isabel& Tormos, Carmen& Egea, Mercedes& Miguel, Amparo…[et al.]. Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-490545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490545