Progress on Antiangiogenic Therapy for Patients with Malignant Glioma
Joint Authors
Gladson, Candece L.
Ahluwalia, Manmeet S.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Glioblastoma (GBM) is the most common primary brain tumor occurring in America.
Despite recent advances in therapeutics, the prognosis for patients with newly diagnosed GBM remains dismal.
As these tumors characteristically show evidence of angiogenesis (neovascularization) there has been great interest in developing anti-angiogenic therapeutic strategies for the treatment of patients with this disease and some anti-angiogenic agents have now been used for the treatment of patients with malignant glioma tumors.
Although the results of these clinical trials are promising in that they indicate an initial therapeutic response, the anti-angiogenic therapies tested to date have not changed the overall survival of patients with malignant glioma tumors.
This is due, in large part, to the development of resistance to these therapies.
Ongoing research into key features of the neovasculature in malignant glioma tumors, as well as the general angiogenesis process, is suggesting additional molecules that may be targeted and an improved response when both the neovasculature and the tumor cells are targeted.
Prevention of the development of resistance may require the development of anti-angiogenic strategies that induce apoptosis or cell death of the neovasculature, as well as an improved understanding of the potential roles of circulating endothelial progenitor cells and vascular co-option by tumor cells, in the development of resistance.
American Psychological Association (APA)
Ahluwalia, Manmeet S.& Gladson, Candece L.. 2010. Progress on Antiangiogenic Therapy for Patients with Malignant Glioma. Journal of Oncology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-490692
Modern Language Association (MLA)
Ahluwalia, Manmeet S.& Gladson, Candece L.. Progress on Antiangiogenic Therapy for Patients with Malignant Glioma. Journal of Oncology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-490692
American Medical Association (AMA)
Ahluwalia, Manmeet S.& Gladson, Candece L.. Progress on Antiangiogenic Therapy for Patients with Malignant Glioma. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-490692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490692