3D Pathology Volumetric Technique : A Method for Calculating Breast Tumour Volume from Whole-Mount Serial Section Images
Joint Authors
Liu, K.
Clarke, G. M.
Holloway, Claire M. B.
Yaffe, M. J.
Murray, M.
Zubovits, J. T.
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Tumour size, most commonly measured by maximum linear extent, remains a strong predictor of survival in breast cancer.
Tumour volume, proportional to the number of tumour cells, may be a more accurate surrogate for size.
We describe a novel “3D pathology volumetric technique” for lumpectomies and compare it with 2D measurements.
Volume renderings and total tumour volume are computed from digitized whole-mount serial sections using custom software tools.
Results are presented for two lumpectomy specimens selected for tumour features which may challenge accurate measurement of tumour burden with conventional, sampling-based pathology: (1) an infiltrative pattern admixed with normal breast elements; (2) a localized invasive mass separated from the in situ component by benign tissue.
Spatial relationships between key features (tumour foci, close or involved margins) are clearly visualized in volume renderings.
Invasive tumour burden can be underestimated using conventional pathology, compared to the volumetric technique (infiltrative pattern: 30% underestimation; localized mass: 3% underestimation for invasive tumour, 44% for in situ component).
Tumour volume approximated from 2D measurements (i.e., maximum linear extent), assuming elliptical geometry, was seen to overestimate volume compared to the 3D volumetric calculation (by a factor of 7x for the infiltrative pattern; 1.5x for the localized invasive mass).
American Psychological Association (APA)
Clarke, G. M.& Murray, M.& Holloway, Claire M. B.& Liu, K.& Zubovits, J. T.& Yaffe, M. J.. 2012. 3D Pathology Volumetric Technique : A Method for Calculating Breast Tumour Volume from Whole-Mount Serial Section Images. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490889
Modern Language Association (MLA)
Clarke, G. M.…[et al.]. 3D Pathology Volumetric Technique : A Method for Calculating Breast Tumour Volume from Whole-Mount Serial Section Images. International Journal of Breast Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-490889
American Medical Association (AMA)
Clarke, G. M.& Murray, M.& Holloway, Claire M. B.& Liu, K.& Zubovits, J. T.& Yaffe, M. J.. 3D Pathology Volumetric Technique : A Method for Calculating Breast Tumour Volume from Whole-Mount Serial Section Images. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-490889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490889