Influence of IL10 (G1082A) and TNFα (G308A) Polymorphisms on the Survival of Pediatric Patients with ALL
Joint Authors
Muniz, Maria Tereza Cartaxo
Lugo, Karina Araújo
de Deus, Dayse Maria Vasconcelos
Source
Leukemia Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Interleukin 10 (IL10) is a pleiotropic cytokine that stimulates various hematopoietic cells.
The tumor necrosis factor alpha (TNFα) is a cytokine that may influence the transcriptional activity induced by glucocorticoids.
This study examined the impact of TNFα (G308A) and IL10 (G1082A) polymorphisms at promoter regions in relation to the overall survival of 105 children (0≤18 years) with acute lymphoblastic leukemia (ALL) for a period of 126 months, treated according to the protocol GBTLI99.
The G1082A and G308A polymorphisms were identified by allele-specific PCR and PCR-RFLP, respectively.
Patients with IL10AA genotype had a higher death ratio (44%, P=0.0089).
Patients with both IL10AA and TNFAA genotypes showed the worst survival when compared with the IL10GG and TNFGA genotypes (P=0.0043).
The results of this study revealed a lower survival among patients with IL10AA genotype and the concomitant occurrence of IL10AA and TNFAA genotypes.
American Psychological Association (APA)
de Deus, Dayse Maria Vasconcelos& Lugo, Karina Araújo& Muniz, Maria Tereza Cartaxo. 2012. Influence of IL10 (G1082A) and TNFα (G308A) Polymorphisms on the Survival of Pediatric Patients with ALL. Leukemia Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490995
Modern Language Association (MLA)
de Deus, Dayse Maria Vasconcelos…[et al.]. Influence of IL10 (G1082A) and TNFα (G308A) Polymorphisms on the Survival of Pediatric Patients with ALL. Leukemia Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-490995
American Medical Association (AMA)
de Deus, Dayse Maria Vasconcelos& Lugo, Karina Araújo& Muniz, Maria Tereza Cartaxo. Influence of IL10 (G1082A) and TNFα (G308A) Polymorphisms on the Survival of Pediatric Patients with ALL. Leukemia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-490995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490995
