Microbial Translocation in Chronic Liver Diseases
Joint Authors
Celesia, Benedetto Maurizio
Di Rosa, Michele
Cacopardo, Bruno
Pinzone, Marilia Rita
Nunnari, Giuseppe
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
The intestinal microflora is not only involved in the digestion of nutrients, but also in local immunity, forming a barrier against pathogenic microorganisms.
The derangement of the gut microflora may lead to microbial translocation, defined as the passage of viable microorganisms or bacterial products (i.e., LPS, lipopeptides) from the intestinal lumen to the mesenteric lymph nodes and other extraintestinal sites.
The most recent evidence suggests that microbial translocation (MT) may occur not only in cirrhosis, but also in the early stage of several liver diseases, including alcoholic hepatopathy and nonalcoholic fatty liver disease.
Different mechanisms, such as small intestinal bacterial overgrowth, increased permeability of intestinal mucosa, and impaired immunity, may favor MT.
Furthermore, MT has been implicated in the pathogenesis of the complications of cirrhosis, which are a significant cause of morbidity and mortality in cirrhotic subjects.
Therapeutic strategies aiming at modulating the gut microflora and reducing MT have focused on antibiotic-based options, such as selective intestinal decontamination, and nonantibiotic-based options, such as prokinetics and probiotics.
In particular, probiotics may represent an attractive strategy, even though the promising results of experimental models and limited clinical studies need to be confirmed in larger randomized trials.
American Psychological Association (APA)
Pinzone, Marilia Rita& Celesia, Benedetto Maurizio& Di Rosa, Michele& Cacopardo, Bruno& Nunnari, Giuseppe. 2012. Microbial Translocation in Chronic Liver Diseases. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-491196
Modern Language Association (MLA)
Pinzone, Marilia Rita…[et al.]. Microbial Translocation in Chronic Liver Diseases. International Journal of Microbiology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-491196
American Medical Association (AMA)
Pinzone, Marilia Rita& Celesia, Benedetto Maurizio& Di Rosa, Michele& Cacopardo, Bruno& Nunnari, Giuseppe. Microbial Translocation in Chronic Liver Diseases. International Journal of Microbiology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-491196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491196