Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model
Joint Authors
al-Harbi, Mohamed M.
Sayed-Ahmed, Mohammed M.
Aleisa, Abdulaziz M.
Hafez, Mohamed M.
Aldelemy, Meshan Lafi
al-Harbi, Naif O.
al-Shabanah, Othman A.
al-Hosaini, Khaled A.
al-Rajai, Salim S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
It is well documented that ifosfamide (IFO) therapy is associated with sever nephropathy in the form of Fanconi syndrome.
Although oxidative stress has been reported as a major player in IFO-induced Fanconi syndrome, no mechanism for this effect has been ascertained.
Therefore, this study has been initiated to investigate, on gene expression level, the mechanism of IFO-induce nephrotoxicity and those whereby carnitine supplementation attenuates this serious side effect of IFO.
To achieve the ultimate goals of this study, adult male rats were assigned to one of four treatment groups, namely, control, L-carnitine, IFO, and IFO plus L-carnitine.
Administration of IFO for 5 days significantly increased serum creatinine, blood urea nitrogen (BUN), and total nitrate/nitrite (NOx) production in kidney tissues.
In addition, IFO significantly increased mRNA expression of inducible nitric oxide synthase (iNOS), caspase-9, and caspase-3 and significantly decreased expression of glutathione peroxides (GPx), catalase (CAT), and Bcl2 in kidney tissues.
Administration of L-carnitine to IFO-treated rats resulted in a complete reversal of the all biochemical and gene expression changes, induced by IFO, to the control values.
Data from this study suggest that L-carnitine prevents the development of IFO-induced nephrotoxicity via downregulation of oxidative and nitrosative apoptotic signaling in kidney tissues.
American Psychological Association (APA)
Sayed-Ahmed, Mohammed M.& Hafez, Mohamed M.& Aldelemy, Meshan Lafi& Aleisa, Abdulaziz M.& al-Rajai, Salim S.& al-Hosaini, Khaled A.…[et al.]. 2012. Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-491377
Modern Language Association (MLA)
Sayed-Ahmed, Mohammed M.…[et al.]. Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-491377
American Medical Association (AMA)
Sayed-Ahmed, Mohammed M.& Hafez, Mohamed M.& Aldelemy, Meshan Lafi& Aleisa, Abdulaziz M.& al-Rajai, Salim S.& al-Hosaini, Khaled A.…[et al.]. Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-491377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491377