Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window
Joint Authors
Sotoyama, Hidekazu
Nawa, Hiroyuki
Namba, Hisaaki
Takei, Nobuyuki
Iwakura, Yuriko
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neuregulin-1 and epidermal growth factor (EGF) are implicated in the pathogenesis of schizophrenia.
To test the developmental hypothesis for schizophrenia, we administered these factors to rodent pups, juveniles, and adults and characterized neurobiological and behavioral consequences.
These factors were also provided from their transgenes or infused into the adult brain.
Here we summarize previous results from these experiments and discuss those from neuropathological aspects.
In the neonatal stage but not the juvenile and adult stages, subcutaneously injected factors penetrated the blood-brain barrier and acted on brain neurons, which later resulted in persistent behavioral and dopaminergic impairments associated with schizophrenia.
Neonatally EGF-treated animals exhibited persistent hyperdopaminergic abnormalities in the nigro-pallido-striatal system while neuregulin-1 treatment resulted in dopaminergic deficits in the corticolimbic dopamine system.
Effects on GABAergic and glutamatergic systems were transient or limited.
Even in the adult stage, intracerebral administration and transgenic expression of these factors produced similar but not identical behavioral impairments, although the effects of intracerebral administration were reversible.
These findings suggest that dopaminergic development is highly vulnerable to circulating ErbB ligands in the pre- and perinatal stages.
Once maldevelopment of the dopaminergic system is established during early development, dopamine-associating behavioral deficits become irreversible and manifest at postpubertal stages.
American Psychological Association (APA)
Nawa, Hiroyuki& Sotoyama, Hidekazu& Iwakura, Yuriko& Takei, Nobuyuki& Namba, Hisaaki. 2014. Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491489
Modern Language Association (MLA)
Nawa, Hiroyuki…[et al.]. Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-491489
American Medical Association (AMA)
Nawa, Hiroyuki& Sotoyama, Hidekazu& Iwakura, Yuriko& Takei, Nobuyuki& Namba, Hisaaki. Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia : Their Target Cells and Time Window. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-491489
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491489