Relowering of Serum Na for Osmotic Demyelinating Syndrome
Joint Authors
Fujita, Toshiro
Ayuzawa, Nobuhiro
Seki, George
Takano, Koji
Yamada, Hideomi
Source
Case Reports in Neurological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
We report a case in whom slow correction of hyponatremia (5 mmol/day for 3 days) induced central pontine myelinolysis (CPM).
After the diagnosis was confirmed by imaging, we started to relower serum Na that completely recovered the sign and symptoms of CPM.
Rapid correction of serum sodium is known to be associated with CPM.
However, it may occur even after slow correction of hyponatremia.
Currently, there is no standard therapy for CPM other than supportive therapy.
Other therapy includes sterioid, plasmaphresis and IVIG, but these therapies have not been shown to be particularly effective.
The pathophysiology of CPM is related to a relative dehydration of the brain during the correction of hyponatremia, resulting in cell death and demyelination, therefore gentle rehydration with lowering serum sodium may not be an unreasonable therapy.
The present case provides supportive evidence that reinduction of hyponatremia is effective in treating CPM if started immediately after the diagnosis is suggested.
The present case tells us that severe chronic hyponatremia must be managed with extreme care especially in patients with chronic debilitating illness and that relowering serum Na is a treatment of choice when CPM is suggested.
American Psychological Association (APA)
Yamada, Hideomi& Takano, Koji& Ayuzawa, Nobuhiro& Seki, George& Fujita, Toshiro. 2012. Relowering of Serum Na for Osmotic Demyelinating Syndrome. Case Reports in Neurological Medicine،Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-491935
Modern Language Association (MLA)
Yamada, Hideomi…[et al.]. Relowering of Serum Na for Osmotic Demyelinating Syndrome. Case Reports in Neurological Medicine No. 2012 (2012), pp.1-2.
https://search.emarefa.net/detail/BIM-491935
American Medical Association (AMA)
Yamada, Hideomi& Takano, Koji& Ayuzawa, Nobuhiro& Seki, George& Fujita, Toshiro. Relowering of Serum Na for Osmotic Demyelinating Syndrome. Case Reports in Neurological Medicine. 2012. Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-491935
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491935