Relowering of Serum Na for Osmotic Demyelinating Syndrome

Joint Authors

Fujita, Toshiro
Ayuzawa, Nobuhiro
Seki, George
Takano, Koji
Yamada, Hideomi

Source

Case Reports in Neurological Medicine

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-2, 2 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-06-28

Country of Publication

Egypt

No. of Pages

2

Main Subjects

Medicine

Abstract EN

We report a case in whom slow correction of hyponatremia (5 mmol/day for 3 days) induced central pontine myelinolysis (CPM).

After the diagnosis was confirmed by imaging, we started to relower serum Na that completely recovered the sign and symptoms of CPM.

Rapid correction of serum sodium is known to be associated with CPM.

However, it may occur even after slow correction of hyponatremia.

Currently, there is no standard therapy for CPM other than supportive therapy.

Other therapy includes sterioid, plasmaphresis and IVIG, but these therapies have not been shown to be particularly effective.

The pathophysiology of CPM is related to a relative dehydration of the brain during the correction of hyponatremia, resulting in cell death and demyelination, therefore gentle rehydration with lowering serum sodium may not be an unreasonable therapy.

The present case provides supportive evidence that reinduction of hyponatremia is effective in treating CPM if started immediately after the diagnosis is suggested.

The present case tells us that severe chronic hyponatremia must be managed with extreme care especially in patients with chronic debilitating illness and that relowering serum Na is a treatment of choice when CPM is suggested.

American Psychological Association (APA)

Yamada, Hideomi& Takano, Koji& Ayuzawa, Nobuhiro& Seki, George& Fujita, Toshiro. 2012. Relowering of Serum Na for Osmotic Demyelinating Syndrome. Case Reports in Neurological Medicine،Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-491935

Modern Language Association (MLA)

Yamada, Hideomi…[et al.]. Relowering of Serum Na for Osmotic Demyelinating Syndrome. Case Reports in Neurological Medicine No. 2012 (2012), pp.1-2.
https://search.emarefa.net/detail/BIM-491935

American Medical Association (AMA)

Yamada, Hideomi& Takano, Koji& Ayuzawa, Nobuhiro& Seki, George& Fujita, Toshiro. Relowering of Serum Na for Osmotic Demyelinating Syndrome. Case Reports in Neurological Medicine. 2012. Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-491935

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-491935