Endocan in Cancers : A Lesson from a Circulating Dermatan Sulfate Proteoglycan
Joint Authors
Delehedde, Maryse
Vivès, Romain R.
Devenyns, Lucie
Maurage, Claude-Alain
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
As most proteoglycans exert their biological activities in the pericellular region, circulating Endocan has appeared since its discovery as an atypical dermatan sulfate proteoglycan, with distinctive structural and functional properties.
Endocan is naturally expressed by endothelial cells, highly regulated in presence of proinflammatory and proangiogenic molecules, binds to matrix proteins, growth factors, integrin, and cells, and may be then considered as an accurate marker of endothelial activation.
Consequently, Endocan expression has been associated with a growing number of pathological conditions where endothelium gets challenged and notably in highly vascularized cancers.
In this context, Endocan has indeed been rapidly emerging as a promising tissue- and blood-based marker of the vascular growth and neoangiogenesis during cancer progression.
Furthermore, very recent studies have reported an expression of Endocan by the tumor cells themselves.
This highlights Endocan as a multifaceted molecule with a great interest for researchers and clinicians to better understand tumor development, from the bench to the clinics.
With promising perspectives of clinical applications, Endocan thus appears as an exciting model for on going and future developments of proteoglycan-based approaches in cancer diagnostics and/or therapy.
American Psychological Association (APA)
Delehedde, Maryse& Devenyns, Lucie& Maurage, Claude-Alain& Vivès, Romain R.. 2013. Endocan in Cancers : A Lesson from a Circulating Dermatan Sulfate Proteoglycan. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-491971
Modern Language Association (MLA)
Delehedde, Maryse…[et al.]. Endocan in Cancers : A Lesson from a Circulating Dermatan Sulfate Proteoglycan. International Journal of Cell Biology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-491971
American Medical Association (AMA)
Delehedde, Maryse& Devenyns, Lucie& Maurage, Claude-Alain& Vivès, Romain R.. Endocan in Cancers : A Lesson from a Circulating Dermatan Sulfate Proteoglycan. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-491971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491971