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Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma
Joint Authors
Hossain, Muhammad Rajib
Kibria, Mahzabin
Nabi, Junaid
Alam, Md. Mashiul
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Adrenocortical tumors (ACTs) causing Cushing’s syndrome are extremely rare in children and adolescents.
Bilateral macronodular adrenocortical disease which is a component of the McCune-Albright syndrome is the most common cause of endogenous Cushing’s syndrome.
We report the case of a boy with Cushing’s syndrome who presented with obesity and growth retardation.
The child was hypertensive.
The biochemical evaluation revealed that his serum cortisol levels were 25.80 μg/dL, with a concomitant plasma ACTH level of 10.0 pg/mL and nonsuppressed serum cortisol on high-dose dexamethasone suppression test (HDDST) to be 20.38 μg/dL.
Computed tomography of the abdomen demonstrated a 8 × 6 × 5 cm left adrenal mass with internal calcifications.
Following preoperative stabilization, laparotomy was carried out which revealed a lobulated left adrenal mass with intact capsule weighing 120 grams.
Histopathological examination revealed a benign cortical neoplastic lesion, suggestive of adrenal adenoma; composed of large polygonal cells with centrally placed nuclei and prominent nucleoli without capsular and vascular invasion.
On the seventh postoperative day, cortisol levels were within normal range indicating biochemical remission of Cushing’s syndrome.
On followup after three months, the patient showed significant clinical improvement and had lost moderate amount of weight and adrenal imaging was found to be normal.
American Psychological Association (APA)
Hossain, Muhammad Rajib& Alam, Md. Mashiul& Nabi, Junaid& Kibria, Mahzabin. 2013. Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma. Case Reports in Endocrinology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-492144
Modern Language Association (MLA)
Hossain, Muhammad Rajib…[et al.]. Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma. Case Reports in Endocrinology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-492144
American Medical Association (AMA)
Hossain, Muhammad Rajib& Alam, Md. Mashiul& Nabi, Junaid& Kibria, Mahzabin. Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma. Case Reports in Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-492144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492144