The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women
Joint Authors
Duława, J.
Więcek, Andrzej
Holecki, M.
Chudek, Jerzy
Titz-Bober, M.
Source
International Journal of Endocrinology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Plasma FGF-23 concentrations and its relationship with calcium-phosphate homeostasis were evaluated in 48 perimenopausal obese women and in 29 nonobese controls.
Serum parathyroid hormone, 25-hydroxyvitamin D3, CTX1, osteocalcin, total calcium, phosphorus, creatinine, and plasma intact FGF-23 concentrations were assessed.
DXA of lumbar spine and femoral neck was performed to determine bone mineral density (BMD).
Plasma iFGF-23 concentration was significantly higher in obese patients (by 42%) and correlated with age and BMD of proximal femur (R=-0.346; R=0.285, resp.) but not with markers of bone turnover.
However, serum phosphorus level in obese subjects was significantly lower.
iFGF-23 concentration correlated significantly with body mass index (R=0.292) and fat content (R=0.259) in all study subjects.
Moreover, a significant correlation between iFGF-23 and iPTH (R=0.254) was found.
No correlation between serum phosphorus or eGFR and plasma iFGF-23 and between eGFR and serum phosphorus was found.
Elevated serum iFGF-23 concentration may partially explain lower phosphorus levels in the obese and seems not to reflect bone turnover.
American Psychological Association (APA)
Holecki, M.& Chudek, Jerzy& Więcek, Andrzej& Titz-Bober, M.& Duława, J.. 2011. The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-492149
Modern Language Association (MLA)
Holecki, M.…[et al.]. The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women. International Journal of Endocrinology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-492149
American Medical Association (AMA)
Holecki, M.& Chudek, Jerzy& Więcek, Andrzej& Titz-Bober, M.& Duława, J.. The Serum Level of Fibroblast Growth Factor-23 and Calcium-Phosphate Homeostasis in Obese Perimenopausal Women. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-492149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492149