Surface Modification of Biomaterials : A Quest for Blood Compatibility
Joint Authors
Seifalian, Alexander Marcus
de Mel, Achala
Cousins, Brian G.
Source
International Journal of Biomaterials
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiovascular implants must resist thrombosis and intimal hyperplasia to maintain patency.
These implants when in contact with blood face a challenge to oppose the natural coagulation process that becomes activated.
Surface protein adsorption and their relevant 3D confirmation greatly determine the degree of blood compatibility.
A great deal of research efforts are attributed towards realising such a surface, which comprise of a range of methods on surface modification.
Surface modification methods can be broadly categorized as physicochemical modifications and biological modifications.
These modifications aim to modulate platelet responses directly through modulation of thrombogenic proteins or by inducing antithrombogenic biomolecules that can be biofunctionalised onto surfaces or through inducing an active endothelium.
Nanotechnology is recognising a great role in such surface modification of cardiovascular implants through biofunctionalisation of polymers and peptides in nanocomposites and through nanofabrication of polymers which will pave the way for finding a closer blood match through haemostasis when developing cardiovascular implants with a greater degree of patency.
American Psychological Association (APA)
de Mel, Achala& Cousins, Brian G.& Seifalian, Alexander Marcus. 2012. Surface Modification of Biomaterials : A Quest for Blood Compatibility. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492204
Modern Language Association (MLA)
de Mel, Achala…[et al.]. Surface Modification of Biomaterials : A Quest for Blood Compatibility. International Journal of Biomaterials No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-492204
American Medical Association (AMA)
de Mel, Achala& Cousins, Brian G.& Seifalian, Alexander Marcus. Surface Modification of Biomaterials : A Quest for Blood Compatibility. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-492204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492204