Gene-Based Antibody Strategies for Prion Diseases

Joint Authors

Cardinale, Alessio
Biocca, Silvia

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-08-21

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Biology

Abstract EN

Prion diseases or transmissible spongiform encephalopathies (TSE) are a group of neurodegenerative and infectious disorders characterized by the conversion of a normal cellular protein PrPC into a pathological abnormally folded form, termed PrPSc.

There are neither available therapies nor diagnostic tools for an early identification of individuals affected by these diseases.

New gene-based antibody strategies are emerging as valuable therapeutic tools.

Among these, intrabodies are chimeric molecules composed by recombinant antibody fragments fused to intracellular trafficking sequences, aimed at inhibiting, in vivo, the function of specific therapeutic targets.

The advantage of intrabodies is that they can be selected against a precise epitope of target proteins, including protein-protein interaction sites and cytotoxic conformers (i.e., oligomeric and fibrillar assemblies).

Herein, we address and discuss in vitro and in vivo applications of intrabodies in prion diseases, focussing on their therapeutic potential.

American Psychological Association (APA)

Cardinale, Alessio& Biocca, Silvia. 2013. Gene-Based Antibody Strategies for Prion Diseases. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-492431

Modern Language Association (MLA)

Cardinale, Alessio& Biocca, Silvia. Gene-Based Antibody Strategies for Prion Diseases. International Journal of Cell Biology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-492431

American Medical Association (AMA)

Cardinale, Alessio& Biocca, Silvia. Gene-Based Antibody Strategies for Prion Diseases. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-492431

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-492431