Gene-Based Antibody Strategies for Prion Diseases
Joint Authors
Cardinale, Alessio
Biocca, Silvia
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Prion diseases or transmissible spongiform encephalopathies (TSE) are a group of neurodegenerative and infectious disorders characterized by the conversion of a normal cellular protein PrPC into a pathological abnormally folded form, termed PrPSc.
There are neither available therapies nor diagnostic tools for an early identification of individuals affected by these diseases.
New gene-based antibody strategies are emerging as valuable therapeutic tools.
Among these, intrabodies are chimeric molecules composed by recombinant antibody fragments fused to intracellular trafficking sequences, aimed at inhibiting, in vivo, the function of specific therapeutic targets.
The advantage of intrabodies is that they can be selected against a precise epitope of target proteins, including protein-protein interaction sites and cytotoxic conformers (i.e., oligomeric and fibrillar assemblies).
Herein, we address and discuss in vitro and in vivo applications of intrabodies in prion diseases, focussing on their therapeutic potential.
American Psychological Association (APA)
Cardinale, Alessio& Biocca, Silvia. 2013. Gene-Based Antibody Strategies for Prion Diseases. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-492431
Modern Language Association (MLA)
Cardinale, Alessio& Biocca, Silvia. Gene-Based Antibody Strategies for Prion Diseases. International Journal of Cell Biology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-492431
American Medical Association (AMA)
Cardinale, Alessio& Biocca, Silvia. Gene-Based Antibody Strategies for Prion Diseases. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-492431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492431