The Effect of Sub-MIC β-Lactam Antibiotic Exposure of Pseudomonas aeruginosa Strains from People with Cystic Fibrosis in a Desiccation Survival Model
Joint Authors
Peckham, Daniel
M'Zali, F.
Denton, Miles
Clifton, I. J.
Source
International Journal of Microbiology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Prior to modern typing methods, cross-infection of P.
aeruginosa between people with cystic fibrosis (CF) was felt to be rare.
Recently a number of studies have demonstrated the presence of clonal strains of P.
aeruginosa infecting people with CF.
The aim of this study was to determine whether strains of P.
aeruginosa demonstrated differences in resistance to desiccation and whether preincubation in subminimum inhibitory concentrations (MICs) of β-lactam affected desiccation resistance.
The experimental data were modelled to a first-order decay model and a Weibull decay model using least squares nonlinear regression.
The Weibull model was the preferred model for the desiccation survival.
The presence of a mucoid phenotype promoted desiccation survival.
Preincubation with antibiotics did not have a consistent effect on the strains of P.
aeruginosa.
Meropenem reduced desiccation resistance, whereas ceftazidime had much less effect on the strains studied.
American Psychological Association (APA)
Clifton, I. J.& Denton, Miles& M'Zali, F.& Peckham, Daniel. 2011. The Effect of Sub-MIC β-Lactam Antibiotic Exposure of Pseudomonas aeruginosa Strains from People with Cystic Fibrosis in a Desiccation Survival Model. International Journal of Microbiology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492553
Modern Language Association (MLA)
Clifton, I. J.…[et al.]. The Effect of Sub-MIC β-Lactam Antibiotic Exposure of Pseudomonas aeruginosa Strains from People with Cystic Fibrosis in a Desiccation Survival Model. International Journal of Microbiology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-492553
American Medical Association (AMA)
Clifton, I. J.& Denton, Miles& M'Zali, F.& Peckham, Daniel. The Effect of Sub-MIC β-Lactam Antibiotic Exposure of Pseudomonas aeruginosa Strains from People with Cystic Fibrosis in a Desiccation Survival Model. International Journal of Microbiology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-492553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492553