The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration
Joint Authors
Richter-Landsberg, Christiane
Vollmer, Grit
Schwarz, Lisa
Source
International Journal of Cell Biology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Filamentous tau-positive protein inclusions in neurons and glia are prominent features of a number of neurodegenerative disorders termed tauopathies.
These inclusions are further characterized by the presence of heat shock proteins (HSPs).
The group of small HSPs, namely, HSP27 and αB-crystallin, interact with the cytoskeleton, bind to nonnative proteins, and prevent their aggregation after stress.
To further investigate their contribution to neurodegenerative diseases, we have analyzed the association of HSP27 with pathological lesions of tauopathies.
Microarray and immunoblot analysis revealed that HSP27 is enhanced at the mRNA and protein levels in affected brains, and that it is associated with astrocytic pathology.
The upregulation of HSP27 in tauopathies with gial pathology implies distinct mechanisms for glial and neuronal cells.
This was sustained by cell culture studies, demonstrating that the small HSPs are specifically and prominently expressed in unstressed astrocytes and not in neurons and in neurons remained at a rather low level even after stress situations.
American Psychological Association (APA)
Schwarz, Lisa& Vollmer, Grit& Richter-Landsberg, Christiane. 2010. The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. International Journal of Cell Biology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-492993
Modern Language Association (MLA)
Schwarz, Lisa…[et al.]. The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. International Journal of Cell Biology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-492993
American Medical Association (AMA)
Schwarz, Lisa& Vollmer, Grit& Richter-Landsberg, Christiane. The Small Heat Shock Protein HSP2527 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. International Journal of Cell Biology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-492993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-492993