Gray’s Time-Varying Coefficients Model for Posttransplant Survival of Pediatric Liver Transplant Recipients with a Diagnosis of Cancer
Joint Authors
Chang, Chung-Chou H.
Kang, Hyung-joo
Zenarosa, Gabriel L.
Donnell, Drew Michael S.
Roberts, Mark S.
Bryce, Cindy L.
Ren, Yi
Tomko, Heather E.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Transplantation is often the only viable treatment for pediatric patients with end-stage liver disease.
Making well-informed decisions on when to proceed with transplantation requires accurate predictors of transplant survival.
The standard Cox proportional hazards (PH) model assumes that covariate effects are time-invariant on right-censored failure time; however, this assumption may not always hold.
Gray’s piecewise constant time-varying coefficients (PC-TVC) model offers greater flexibility to capture the temporal changes of covariate effects without losing the mathematical simplicity of Cox PH model.
In the present work, we examined the Cox PH and Gray PC-TVC models on the posttransplant survival analysis of 288 pediatric liver transplant patients diagnosed with cancer.
We obtained potential predictors through univariable (P<0.15) and multivariable models with forward selection (P<0.05) for the Cox PH and Gray PC-TVC models, which coincide.
While the Cox PH model provided reasonable average results in estimating covariate effects on posttransplant survival, the Gray model using piecewise constant penalized splines showed more details of how those effects change over time.
American Psychological Association (APA)
Ren, Yi& Chang, Chung-Chou H.& Zenarosa, Gabriel L.& Tomko, Heather E.& Donnell, Drew Michael S.& Kang, Hyung-joo…[et al.]. 2013. Gray’s Time-Varying Coefficients Model for Posttransplant Survival of Pediatric Liver Transplant Recipients with a Diagnosis of Cancer. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-493161
Modern Language Association (MLA)
Ren, Yi…[et al.]. Gray’s Time-Varying Coefficients Model for Posttransplant Survival of Pediatric Liver Transplant Recipients with a Diagnosis of Cancer. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-493161
American Medical Association (AMA)
Ren, Yi& Chang, Chung-Chou H.& Zenarosa, Gabriel L.& Tomko, Heather E.& Donnell, Drew Michael S.& Kang, Hyung-joo…[et al.]. Gray’s Time-Varying Coefficients Model for Posttransplant Survival of Pediatric Liver Transplant Recipients with a Diagnosis of Cancer. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-493161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493161