Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis
Joint Authors
Watabe, Tetsuro
Yoshimatsu, Yasuhiro
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Most cardiac diseases caused by inflammation are associated with fibrosis in the heart.
Fibrosis is characterized by the accumulation of fibroblasts and excess deposition of extracellular matrix (ECM), which results in the distorted organ architecture and function.
Recent studies revealed that cardiac fibroblasts are heterogeneous with multiple origins.
Endothelial-mesenchymal transition (EndMT) plays important roles in the formation of cardiac fibroblasts during pathological settings.
EndMT is regulated by signaling pathways mediated by cytokines including transforming growth factor (TGF)-β.
Better understanding of the mechanisms of the formation of cardiac fibroblasts via EndMT may provide an opportunity to develop therapeutic strategies to cure heart diseases.
American Psychological Association (APA)
Yoshimatsu, Yasuhiro& Watabe, Tetsuro. 2011. Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493506
Modern Language Association (MLA)
Yoshimatsu, Yasuhiro& Watabe, Tetsuro. Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis. International Journal of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-493506
American Medical Association (AMA)
Yoshimatsu, Yasuhiro& Watabe, Tetsuro. Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-493506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493506