Redefining Lumpectomy Using a Modification of the “Sick Lobe” Hypothesis and Ductal Anatomy
Joint Authors
Bong, J.
Dooley, William C.
Parker, J.
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objectives.
The “Sick Lobe” hypothesis states that breast cancers evolve from entire lobes or portions of lobes of the breast where initiation events have occurred early in development.
The implication is that some cancers are isolated events and others are truly multi-focal but limited to single lobar-ductal units.
Methods.
This is a single surgeon retrospective review of early stage breast cancer lumpectomy patients treated from 1/2000 to 2/2005.
Ductal endoscopy was used direct lumpectomy surgical margins by defining ductal anatomy and mapping proliferative changes within the sick lobe for complete excision.
Results.
Breast conservation surgery for stage 0–2 breast cancer with an attempt to perform endoscopy in association with therapeutic lumpectomy was performed in 554 patients (successful endoscopy in 465 cases).
With an average followup of >5 years for the entire group, annual hazard rate for local failure in traditional lumpectomy without ductal mapping was 0.97%/yr.
and for lumpectomy with ductal mapping and excision of entire sick lobe was 0.18%/yr.
With endoscopy, 42% of patients were found to have extensive disease within their “sick lobe.” Conclusions.
Targeting breast cancer lumpectomy using endoscopy and excision of regional associated proliferation seems associated with lower recurrence in this non-randomized series.
American Psychological Association (APA)
Dooley, William C.& Bong, J.& Parker, J.. 2011. Redefining Lumpectomy Using a Modification of the “Sick Lobe” Hypothesis and Ductal Anatomy. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-493749
Modern Language Association (MLA)
Dooley, William C.…[et al.]. Redefining Lumpectomy Using a Modification of the “Sick Lobe” Hypothesis and Ductal Anatomy. International Journal of Breast Cancer No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-493749
American Medical Association (AMA)
Dooley, William C.& Bong, J.& Parker, J.. Redefining Lumpectomy Using a Modification of the “Sick Lobe” Hypothesis and Ductal Anatomy. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-493749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-493749