Muscle Plasticity and β2-Adrenergic Receptors : Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy
Joint Authors
Shirato, Ken
Tachiyashiki, Kaoru
Imaizumi, Kazuhiko
Sato, Shogo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We discuss the functional roles of β2-adrenergic receptors in skeletal muscle hypertrophy and atrophy as well as the adaptive responses of β2-adrenergic receptor expression to anabolic and catabolic conditions.
β2-Adrenergic receptor stimulation using anabolic drugs increases muscle mass by promoting muscle protein synthesis and/or attenuating protein degradation.
These effects are prevented by the downregulation of the receptor.
Endurance training improves oxidative performance partly by increasing β2-adrenergic receptor density in exercise-recruited slow-twitch muscles.
However, excessive stimulation of β2-adrenergic receptors negates their beneficial effects.
Although the preventive effects of β2-adrenergic receptor stimulation on atrophy induced by muscle disuse and catabolic hormones or drugs are observed, these catabolic conditions decrease β2-adrenergic receptor expression in slow-twitch muscles.
These findings present evidence against the use of β2-adrenergic agonists in therapy for muscle wasting and weakness.
Thus, β2-adrenergic receptors in the skeletal muscles play an important physiological role in the regulation of protein and energy balance.
American Psychological Association (APA)
Sato, Shogo& Shirato, Ken& Tachiyashiki, Kaoru& Imaizumi, Kazuhiko. 2011. Muscle Plasticity and β2-Adrenergic Receptors : Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494038
Modern Language Association (MLA)
Sato, Shogo…[et al.]. Muscle Plasticity and β2-Adrenergic Receptors : Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-494038
American Medical Association (AMA)
Sato, Shogo& Shirato, Ken& Tachiyashiki, Kaoru& Imaizumi, Kazuhiko. Muscle Plasticity and β2-Adrenergic Receptors : Adaptive Responses of β2-Adrenergic Receptor Expression to Muscle Hypertrophy and Atrophy. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-494038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494038