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Combination PPARγ and RXR Agonist Treatment in Melanoma Cells : Functional Importance of S100A2
Joint Authors
Klopper, Joshua P.
Bissonnette, Reid
Haugen, Bryan R.
Sharma, Vibha
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Nuclear hormone receptors, including RXR and PPARγ, represent novel therapeutic targets in melanoma.
We have previously shown that the DRO subline of the amelanotic melanoma A375 responds to rexinoid and thiazolidinedione (TZD) treatment in vitro and in vivo.
We performed microarray analysis of A375(DRO) after TZD and combination rexinoid/TZD treatment in which the calcium binding protein S100A2 had increased expression after rexinoid or TZD treatment and a synergistic increase to combination treatment.
Increased S100A2 expression is dependent on an intact PPARγ receptor, but it is not sufficient to mediate the antiproliferative effects of rexinoid/TZD treatment.
Over expression of S100A2 enhanced the effect of rexinoid and TZD treatment while inhibition of S100A2 expression attenuated the response to rexinoid/TZD treatment, suggesting that S100A2 is necessary for optimal response to RXR and PPARγ activation by respective ligands.
In summary, we have identified potential downstream mediators of rexinoid and TZD treatment in a poorly differentiated melanoma and found that alterations in S100A2 expression affect RXR and PPARγ signaling in A375(DRO) cells.
These studies provide insight into potential mechanisms of tumor response or resistance to these novel therapies.
American Psychological Association (APA)
Klopper, Joshua P.& Sharma, Vibha& Bissonnette, Reid& Haugen, Bryan R.. 2009. Combination PPARγ and RXR Agonist Treatment in Melanoma Cells : Functional Importance of S100A2. PPAR Research،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-494071
Modern Language Association (MLA)
Klopper, Joshua P.…[et al.]. Combination PPARγ and RXR Agonist Treatment in Melanoma Cells : Functional Importance of S100A2. PPAR Research No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-494071
American Medical Association (AMA)
Klopper, Joshua P.& Sharma, Vibha& Bissonnette, Reid& Haugen, Bryan R.. Combination PPARγ and RXR Agonist Treatment in Melanoma Cells : Functional Importance of S100A2. PPAR Research. 2009. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-494071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494071