Autoimmune Cytopenias in Chronic Lymphocytic Leukemia
Joint Authors
Trino, Stefania
Musto, Pellegrino
De Martino, Laura
Condelli, Valentina
La Rocca, Francesco
D'Arena, Giovanni
De Feo, Vincenzo
Guariglia, Roberto
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The clinical course of chronic lymphocytic leukemia (CLL) may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP).
Pure red cell aplasia (PRCA) and autoimmune agranulocytosis (AG) are, indeed, more rarely seen.
However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity.
The source of autoantibodies is still uncertain, despite the most convincing data are in favor of the involvement of resting normal B-cells.
In general, excluding the specific treatment of underlying CLL, the managementof these complications is not different from that of idiopathic autoimmune cytopenias or of those associated to other causes.
Among different therapeutic approaches, monoclonal antibody rituximab, given alone or in combination, has shown to be very effective.
American Psychological Association (APA)
D'Arena, Giovanni& Guariglia, Roberto& La Rocca, Francesco& Trino, Stefania& Condelli, Valentina& De Martino, Laura…[et al.]. 2013. Autoimmune Cytopenias in Chronic Lymphocytic Leukemia. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-494073
Modern Language Association (MLA)
D'Arena, Giovanni…[et al.]. Autoimmune Cytopenias in Chronic Lymphocytic Leukemia. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-494073
American Medical Association (AMA)
D'Arena, Giovanni& Guariglia, Roberto& La Rocca, Francesco& Trino, Stefania& Condelli, Valentina& De Martino, Laura…[et al.]. Autoimmune Cytopenias in Chronic Lymphocytic Leukemia. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-494073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494073