Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada
Joint Authors
Figueiredo, Regina Célia Bressan Queiroz
Nascimento, Silene Carneiro do
da Câmara, Cláudio A. G.
Nerys, Laís L. de A.
Ramos, Eduardo H. S.
Moraes, Marcílio M.
Militão, Gardenia Carmen Gadelha
da Silva, Teresinha Gonçalves
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The essential oils from Mangifera indica var.
Rosa and Espada latex were obtained by hydrodistillation and analyzed using GC-FID and GC-MS.
Twenty-seven components were identified.
The main compound in the essential oil from M.
indica var.
Espada (EOMiE) was terpinolene (73.6%).
The essential oil of M.
indica var.
Rosa (EOMiR) was characterized by high amounts of β-pinene (40.7%) and terpinolene (28.3%).
In the test for leishmanicidal activity against promastigotes forms of L.
amazonensis, EOMiR and EOMiE showed IC50 (72 h) of 39.1 and 23.0 μg/mL, respectively.
In macrophages, EOMiR and EOMiE showed CC50 of 142.84 and 158.65 μg/mL, respectively.
However, both were more specific to the parasite than macrophages, with values of selectivity index of 6.91 for EOMiE and 3.66 for EOMiR.
The essential oils were evaluated for their cytotoxicity against the human tumor cells HEp-2, HT-29, NCI-H292, and HL-60.
The EOMiR and EOMiE were most effective against the HL-60, with IC50 values of 12.3 and 3.6 μg/mL, respectively.
The results demonstrated that the essential oils of M.
indica can destroy L.
amazonensis and inhibit tumor cell growth.
These findings contribute to the knowledge of the Brazilian biodiversity as a source of potential therapeutic agents.
American Psychological Association (APA)
Ramos, Eduardo H. S.& Moraes, Marcílio M.& Nerys, Laís L. de A.& Nascimento, Silene Carneiro do& Militão, Gardenia Carmen Gadelha& Figueiredo, Regina Célia Bressan Queiroz…[et al.]. 2014. Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-494446
Modern Language Association (MLA)
Ramos, Eduardo H. S.…[et al.]. Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-494446
American Medical Association (AMA)
Ramos, Eduardo H. S.& Moraes, Marcílio M.& Nerys, Laís L. de A.& Nascimento, Silene Carneiro do& Militão, Gardenia Carmen Gadelha& Figueiredo, Regina Célia Bressan Queiroz…[et al.]. Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-494446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494446