Validation of an XCTfDOT System on Mice
Joint Authors
Coll, Jean-Luc
Planat-Chrétien, Anne
Hassler, Kai
Dikaiou, Katerina
Vats, Divya
Rudin, Markus
Coutard, Jean-Guillaume
Bucher, Martina
Dinten, Jean-Marc
Koenig, Anne
Hervé, Lionel
Brambilla, Marco
Josserand, Véronique
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In this paper we present systems for dual modality imaging, combining fluorescence-enhanced diffuse optical tomography and X-ray computed tomography.
Fluorescence diffuse optical tomography is carried out in a cylindrical geometry, which ensures optimal sampling and a straight forward integration with the X-ray modality.
Specific acquisition protocols and reconstruction software have been developed to this end.
The X-ray computed tomography serves two purposes.
First, it provides the anatomical information in the registered dual modality images.
Second, it provides the actual shape and boundaries of the animal as a priori input to the fluorescence reconstruction algorithm.
To evaluate the performance of the optical imaging system, experiments have been conducted on phantoms, mice with inserted fluorescing capillaries, and finally on mice bearing tumors, ex-vivo and in-vivo.
Experiments on mice with capillaries inserted in different region of interest, allow estimating the detection limits of fluorophore concentrations.
The fluorescence reconstructions are shown to be geometrically consistent with the X-ray images.
Finally we demonstrate the capability of the bimodal system to localize real tumours in mice in-vivo.
These results show that dual modality fluorescence-enhanced diffuse optical tomography and X-ray computed tomography imaging in cylindrical geometry has a high potential for small animal tumour evolution studies.
American Psychological Association (APA)
Koenig, Anne& Planat-Chrétien, Anne& Hassler, Kai& Bucher, Martina& Coutard, Jean-Guillaume& Hervé, Lionel…[et al.]. 2012. Validation of an XCTfDOT System on Mice. ISRN Optics،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494471
Modern Language Association (MLA)
Koenig, Anne…[et al.]. Validation of an XCTfDOT System on Mice. ISRN Optics No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-494471
American Medical Association (AMA)
Koenig, Anne& Planat-Chrétien, Anne& Hassler, Kai& Bucher, Martina& Coutard, Jean-Guillaume& Hervé, Lionel…[et al.]. Validation of an XCTfDOT System on Mice. ISRN Optics. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-494471