Validation of an XCTfDOT System on Mice

Joint Authors

Coll, Jean-Luc
Planat-Chrétien, Anne
Hassler, Kai
Dikaiou, Katerina
Vats, Divya
Rudin, Markus
Coutard, Jean-Guillaume
Bucher, Martina
Dinten, Jean-Marc
Koenig, Anne
Hervé, Lionel
Brambilla, Marco
Josserand, Véronique

Source

ISRN Optics

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-04-12

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Physics

Abstract EN

In this paper we present systems for dual modality imaging, combining fluorescence-enhanced diffuse optical tomography and X-ray computed tomography.

Fluorescence diffuse optical tomography is carried out in a cylindrical geometry, which ensures optimal sampling and a straight forward integration with the X-ray modality.

Specific acquisition protocols and reconstruction software have been developed to this end.

The X-ray computed tomography serves two purposes.

First, it provides the anatomical information in the registered dual modality images.

Second, it provides the actual shape and boundaries of the animal as a priori input to the fluorescence reconstruction algorithm.

To evaluate the performance of the optical imaging system, experiments have been conducted on phantoms, mice with inserted fluorescing capillaries, and finally on mice bearing tumors, ex-vivo and in-vivo.

Experiments on mice with capillaries inserted in different region of interest, allow estimating the detection limits of fluorophore concentrations.

The fluorescence reconstructions are shown to be geometrically consistent with the X-ray images.

Finally we demonstrate the capability of the bimodal system to localize real tumours in mice in-vivo.

These results show that dual modality fluorescence-enhanced diffuse optical tomography and X-ray computed tomography imaging in cylindrical geometry has a high potential for small animal tumour evolution studies.

American Psychological Association (APA)

Koenig, Anne& Planat-Chrétien, Anne& Hassler, Kai& Bucher, Martina& Coutard, Jean-Guillaume& Hervé, Lionel…[et al.]. 2012. Validation of an XCTfDOT System on Mice. ISRN Optics،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494471

Modern Language Association (MLA)

Koenig, Anne…[et al.]. Validation of an XCTfDOT System on Mice. ISRN Optics No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-494471

American Medical Association (AMA)

Koenig, Anne& Planat-Chrétien, Anne& Hassler, Kai& Bucher, Martina& Coutard, Jean-Guillaume& Hervé, Lionel…[et al.]. Validation of an XCTfDOT System on Mice. ISRN Optics. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-494471

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-494471