Beneficial Effect of 7-O-Galloyl-D-sedoheptulose, a Polyphenol Isolated from Corni Fructus, against Diabetes-Induced Alterations in Kidney and Adipose Tissue of Type 2 Diabetic dbdb Mice

Joint Authors

Yokozawa, Takako
Noh, Jeong Sook
Park, Jong Cheol
Park, Chan Hum

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-11-20

Country of Publication

Egypt

No. of Pages

16

Main Subjects

Medicine

Abstract EN

Traditional medicines are being focused on as possible treatments for diabetes and its complications because of their negligible toxic and/or side effects.

In line with this, our group has reported that Corni Fructus, a traditional medicine considered exhibiting beneficial effects on liver and kidney functions, possessed an antidiabetic effect via ameliorating glucose-mediated metabolic disorders.

To add to these findings, we screened the iridoid glycoside fraction containing morroniside and loganin, and low molecular weight polyphenol fraction containing 7-O-galloyl-d-sedoheptulose (GS) from Corni Fructus.

To our knowledge, GS is a compound only detected in Corni Fructus, and its biological activity has been poorly understood until now.

For these reasons, we examined whether GS has an ameliorative effect on diabetic changes using type 2 diabetic db/db mice.

Our findings suggest that GS has a beneficial effect on the pathological state of the serum, kidney, and adipose tissue related to diabetic damage.

American Psychological Association (APA)

Park, Chan Hum& Noh, Jeong Sook& Park, Jong Cheol& Yokozawa, Takako. 2013. Beneficial Effect of 7-O-Galloyl-D-sedoheptulose, a Polyphenol Isolated from Corni Fructus, against Diabetes-Induced Alterations in Kidney and Adipose Tissue of Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-494641

Modern Language Association (MLA)

Park, Chan Hum…[et al.]. Beneficial Effect of 7-O-Galloyl-D-sedoheptulose, a Polyphenol Isolated from Corni Fructus, against Diabetes-Induced Alterations in Kidney and Adipose Tissue of Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-494641

American Medical Association (AMA)

Park, Chan Hum& Noh, Jeong Sook& Park, Jong Cheol& Yokozawa, Takako. Beneficial Effect of 7-O-Galloyl-D-sedoheptulose, a Polyphenol Isolated from Corni Fructus, against Diabetes-Induced Alterations in Kidney and Adipose Tissue of Type 2 Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-494641

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-494641