Electrospun Polyhydroxybutyrate and Poly(L-lactide-co-ε-caprolactone) Composites as Nanofibrous Scaffolds
Joint Authors
Foster, Leslie John Ray
Molloy, Robert
Punyodom, Winita
Chan, Rodman T. H.
Wanandy, Nico S.
Daranarong, Donraporn
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Electrospinning can produce nanofibrous scaffolds that mimic the architecture of the extracellular matrix and support cell attachment for tissue engineering applications.
In this study, fibrous membranes of polyhydroxybutyrate (PHB) with various loadings of poly(L-lactide-co-ε-caprolactone) (PLCL) were successfully prepared by electrospinning.
In comparison to PLCL scaffolds, PLCL blends with PHB exhibited more irregular fibre diameter distributions and higher average fibre diameters but there were no significant differences in pore size.
PLCL/PHB scaffolds were more hydrophilic (<120°) with significantly reduced tensile strength (ca.
1 MPa) compared to PLCL scaffolds (150.9±2.8∘ and 5.8±0.5 MPa).
Increasing PLCL loading in PHB/PLCL scaffolds significantly increased the extension at break, (4–6-fold).
PLCL/PHB scaffolds supported greater adhesion and proliferation of olfactory ensheathing cells (OECs) than those exhibiting asynchronous growth on culture plates.
Mitochondrial activity of cells cultivated on the electrospun blended membranes was enhanced compared to those grown on PLCL and PHB scaffolds (212, 179, and 153%, resp.).
Analysis showed that PLCL/PHB nanofibrous membranes promoted cell cycle progression and reduced the onset of necrosis.
Thus, electrospun PLCL/PHB composites promoted adhesion and proliferation of OECs when compared to their individual PLCL and PHB components suggesting potential in the repair and engineering of nerve tissue.
American Psychological Association (APA)
Daranarong, Donraporn& Chan, Rodman T. H.& Wanandy, Nico S.& Molloy, Robert& Punyodom, Winita& Foster, Leslie John Ray. 2014. Electrospun Polyhydroxybutyrate and Poly(L-lactide-co-ε-caprolactone) Composites as Nanofibrous Scaffolds. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-495041
Modern Language Association (MLA)
Daranarong, Donraporn…[et al.]. Electrospun Polyhydroxybutyrate and Poly(L-lactide-co-ε-caprolactone) Composites as Nanofibrous Scaffolds. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-495041
American Medical Association (AMA)
Daranarong, Donraporn& Chan, Rodman T. H.& Wanandy, Nico S.& Molloy, Robert& Punyodom, Winita& Foster, Leslie John Ray. Electrospun Polyhydroxybutyrate and Poly(L-lactide-co-ε-caprolactone) Composites as Nanofibrous Scaffolds. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-495041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495041