PPARδ Activity in Cardiovascular Diseases : A Potential Pharmacological Target
Joint Authors
Tesse, Angela
Andriantsitohaina, Ramaroson
Ragot, Thierry
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Activation of peroxisome proliferator-activated receptors (PPARs), and particularly of PPARα and PPARγ, using selective agonists, is currently used in the treatment of metabolic diseases such as hypertriglyceridemia and type 2 diabetes mellitus.
PPARα and PPARγ anti-inflammatory, antiproliferative and antiangiogenic properties in cardiovascular cells were extensively clarified in a variety of in vitro and in vivo models.
In contrast, the role of PPARδ in cardiovascular system is poorly understood.
Prostacyclin, the predominant prostanoid released by vascular cells, is a putative endogenous agonist for PPARδ, but only recently PPARδ selective synthetic agonists were found, improving studies about the physiological and pathophysiological roles of PPARδ activation.
Recent reports suggest that the PPARδ activation may play a pivotal role to regulate inflammation, apoptosis, and cell proliferation, suggesting that this transcriptional factor could become an interesting pharmacological target to regulate cardiovascular cell apoptosis, proliferation, inflammation, and metabolism.
American Psychological Association (APA)
Tesse, Angela& Andriantsitohaina, Ramaroson& Ragot, Thierry. 2009. PPARδ Activity in Cardiovascular Diseases : A Potential Pharmacological Target. PPAR Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-495350
Modern Language Association (MLA)
Tesse, Angela…[et al.]. PPARδ Activity in Cardiovascular Diseases : A Potential Pharmacological Target. PPAR Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-495350
American Medical Association (AMA)
Tesse, Angela& Andriantsitohaina, Ramaroson& Ragot, Thierry. PPARδ Activity in Cardiovascular Diseases : A Potential Pharmacological Target. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-495350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495350