Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea
Joint Authors
Li, Dichen
Jin, Zhongmin
Zhang, Weijie
Bian, Weiguo
He, Jiankang
Hao, Dingjun
Wang, Kunzheng
Lian, Qin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Increasing evidences show that subchondral bone may play a significant role in the repair or progression of cartilage damage in situ.
However, the exact change of subchondral bone during osteochondral repair is still poorly understood.
In this paper, biphasic osteochondral composite scaffolds were fabricated by 3D printing technology using PEG hydrogel and β-TCP ceramic and then implanted in rabbit trochlea within a critical size defect model.
Animals were euthanized at 1, 2, 4, 8, 16, 24, and 52 weeks after implantation.
Histological results showed that hyaline-like cartilage formed along with white smooth surface and invisible margin at 24 weeks postoperatively, typical tidemark formation at 52 weeks.
The repaired subchondral bone formed from 16 to 52 weeks in a “flow like” manner from surrounding bone to the defect center gradually.
Statistical analysis illustrated that both subchondral bone volume and migration area percentage were highly correlated with the gross appearance Wayne score of repaired cartilage.
Therefore, subchondral bone migration is related to cartilage repair for critical size osteochondral defects.
Furthermore, the subchondral bone remodeling proceeds in a “flow like” manner and repaired cartilage with tidemark implies that the biphasic PEG/β-TCP composites fabricated by 3D printing provides a feasible strategy for osteochondral tissue engineering application.
American Psychological Association (APA)
Zhang, Weijie& Lian, Qin& Li, Dichen& Wang, Kunzheng& Hao, Dingjun& Bian, Weiguo…[et al.]. 2014. Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea. BioMed Research International،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-495381
Modern Language Association (MLA)
Zhang, Weijie…[et al.]. Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea. BioMed Research International No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-495381
American Medical Association (AMA)
Zhang, Weijie& Lian, Qin& Li, Dichen& Wang, Kunzheng& Hao, Dingjun& Bian, Weiguo…[et al.]. Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites : A One-Year-Period Study in Rabbit Trochlea. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-495381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495381