Combination Therapy of PPARγ Ligands and Inhibitors of Arachidonic Acid in Lung Cancer
Joint Authors
Mulshine, James L.
Tauler, Jordi
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Lung cancer is the leading cause of cancer death in the United States and five-year survival remains low.
Numerous studies have shown that chronic inflammation may lead to progression of carcinogenesis.
As a result of inflammatory stimulation, arachidonic acid (AA) metabolism produces proliferation mediators through complex and dynamic interactions of the products of the LOX/COX enzymes.
One important mediator in the activation of the AA pathways is the nuclear protein PPARγ.
Targeting LOX/COX enzymes and inducing activation of PPARγ have resulted in significant reduction of cell growth in lung cancer cell lines.
However, specific COX-inhibitors have been correlated with an increased cardiovascular risk.
Clinical applications are still being explored with a novel generation of dual LOX/COX inhibitors.
PPARγ activation through synthetic ligands (TZDs) has revealed a great mechanistic complexity since effects are produced through PPARγ-dependent and -independent mechanisms.
Furthermore, PPARγ could also be involved in regulation of COX-2.
Overexpression of PPARγ has reported to play a role in control of invasion and differentiation.
Exploring the function of PPARγ, in this new context, may provide a better mechanistic model of its role in cancer and give an opportunity to design a more efficient therapeutic approach in combination with LOX/COX inhibitors.
American Psychological Association (APA)
Tauler, Jordi& Mulshine, James L.. 2009. Combination Therapy of PPARγ Ligands and Inhibitors of Arachidonic Acid in Lung Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-495745
Modern Language Association (MLA)
Tauler, Jordi& Mulshine, James L.. Combination Therapy of PPARγ Ligands and Inhibitors of Arachidonic Acid in Lung Cancer. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-495745
American Medical Association (AMA)
Tauler, Jordi& Mulshine, James L.. Combination Therapy of PPARγ Ligands and Inhibitors of Arachidonic Acid in Lung Cancer. PPAR Research. 2009. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-495745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-495745